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Purpose The in vitro and in vivo evaluation of the selective, high affinity (human CB1 IC50 0.49 nM) inverse agonist CB1R tracer [11C]CB-119, a close analog of the previously disclosed [18F]MK-9470, was undertaken. Procedures [11C]CB-119 was synthesized with high specific activity by alkylation of a phenolic precursor with [11C]methyl iodide. In vitro autoradiographic studies using rhesus brain...
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