Search results for: Robert A. Byrne

Items from 1 to 20 out of 104 results

article

A prospective trial of a novel low‐dose paclitaxel‐coated balloon therapy in patients with restenosis in drug‐eluting coronary stents Intracoronary Stenting and Angiographic Results: Optimizing Treatment of Drug Eluting Stent In‐stent REstenosis 3A (ISAR‐DESIRE 3A)

Sebastian Kufner, Himanshu Rai, Jens Wiebe, Felix Altevogt, more

Catheterization and Cardiovascular Interventions > 99 > 3 > 754 - 762

Objectives We investigated the clinical efficacy of a paclitaxel‐coated balloon (PCB) with a novel matrix coating and reduced drug concentration in comparison with a widely used PCB with iopromide excipient. Methods We prospectively enrolled patients with restenosis in drug‐eluting stents. All patients were treated with a novel low‐dose PCB with citrate‐based excipient (Agent PCB). Angiographic...

article

Angiographic performance of everolimus‐eluting stents for the treatment of coronary in‐stent restenosis in daily practice

Jens Wiebe, Himanshu Rai, Constantin Kuna, Salvatore Cassese, more

Catheterization and Cardiovascular Interventions > 98 > 5 > 857 - 862

Objectives The present study aims to analyze the angiographic anti‐restenotic performance of durable polymer everolimus‐eluting stents (EES) for the treatment of in‐stent restenosis (ISR) in daily practice. Background Randomized data is available supporting the use of drug‐coated balloons and drug‐eluting stents for the treatment of ISR; however, additional real‐world data including angiographic...

article

Efficacy of drug‐coated balloon angioplasty in early versus late occurring drug‐eluting stent restenosis: A pooled analysis from the randomized ISAR DESIRE 3 and DESIRE 4 trials

Tobias Koch, Salvatore Cassese, Erion Xhepa, Katharina Mayer, more

Catheterization and Cardiovascular Interventions > 96 > 5 > 1008 - 1015

Background Whether there exist differences concerning clinical outcomes between patients presenting with early versus late DES‐ISR undergoing treatment with drug‐coated balloons (DCB) remains a scientific knowledge gap. Methods This is a pooled analysis including patients with DES‐ISR assigned to treatment with DCB in the setting of the ISAR DESIRE 3 and 4 trials. Clinical outcomes were evaluated...

article

Outcome after new generation single‐layer polytetrafluoroethylene‐covered stent implantation for the treatment of coronary artery perforation

Sebastian Kufner, Nora Schacher, Miroslaw Ferenc, Christian Schlundt, more

Catheterization and Cardiovascular Interventions > 93 > 5 > 912 - 920

Aims Coronary artery perforation (CAP) is a rare but severe complication during percutaneous coronary intervention (PCI). Implantation of covered stents (CS) represents a potentially life‐saving treatment. Concerns exist regarding limited efficacy and high stent thrombosis (ST) rates related to early generation CS. The aim of this study was to evaluate angiographic and clinical outcomes of patients...

article

Qualitative and quantitative neointimal characterization by optical coherence tomography in patients presenting with in-stent restenosis

Erion Xhepa, Robert A. Byrne, Fernando Rivero, Andi Rroku, more

Clinical Research in Cardiology > 2019 > 108 > 9 > 1059-1068

Aims To describe optical coherence tomography (OCT) findings in patients with in-stent restenosis (ISR) and determine predictors of neointimal patterns and neoatherosclerosis. Methods and results Patients undergoing OCT prior to PCI for ISR in three European centres were included. Analyses were performed in a core laboratory. Qualitative and quantitative [gray-scale signal intensity (GSI)] neointima...

article

Incidence and predictors of reCurrent restenosis after drug-coated balloon Angioplasty for Restenosis of a drUg-eluting Stent: The ICARUS Cooperation

Salvatore Cassese, Bo Xu, Seiji Habara, Harald Rittger, more

Revista Espa�ola de Cardiolog�a (English Edition) > 2018 > 71 > 8 > 620-627

The incidence and predictors of recurrent restenosis after drug-coated balloon (DCB) angioplasty for drug-eluting stent (DES) restenosis remain poorly studied. We sought to evaluate the incidence and predictors of recurrent restenosis among participants in randomized controlled trials receiving DCB angioplasty for DES restenosis.The clinical and lesion data of individuals enrolled in 6 randomized...

article

Neoatherosclerosis in Patients With Coronary Stent Thrombosis

Michael Joner, Tobias Koppara, Robert A. Byrne, Maria Isabel Castellanos, more

JACC: Cardiovascular Interventions > 2018 > 11 > 14 > 1340-1350

The purpose of this study was to assess neoatherosclerosis in a registry of prospectively enrolled patients presenting with stent thrombosis using optical coherence tomography.In-stent neoatherosclerosis was recently identified as a novel disease manifestation of atherosclerosis after coronary stent implantation.Angiography and intravascular optical coherence tomography were used to investigate etiologic...

article

Randomised comparison of vascular response to biodegradable polymer sirolimus eluting and permanent polymer everolimus eluting stents: An optical coherence tomography study

Tobias Koppara, Tomohisa Tada, Erion Xhepa, Sebastian Kufner, more

International Journal of Cardiology > 2018 > 258 > C > 42-49

Drug-eluting stents with biodegradable polymer coatings have shown promising outcomes in randomised studies.We compared neointimal healing patterns including strut coverage and assessed neointimal maturity using a novel algorithm in coronary lesions treated with sirolimus-eluting stents with biodegradable polymer coating (BP-SES) or everolimus eluting stents with permanent polymer coating (PP-EES)...

article

Comparative efficacy of two paclitaxel-coated balloons with different excipient coatings in patients with coronary in-stent restenosis

Roisin Colleran, Michael Joner, Sebastian Kufner, Felix Altevogt, more

International Journal of Cardiology > 2018 > 252 > C > 57-62

Angioplasty with paclitaxel-coated balloons (PCB) is recommended for treatment of patients with coronary in-stent restenosis (ISR) according to European clinical practice guidelines. Most clinical trials have investigated iopromide-based PCB and there is a paucity of data comparing efficacy against butyryl-tri-hexyl citrate (BTHC)-based PCB. Our aim was to compare the performance of two widely-used...

article

Special article 2017 ESC focused update on dual antiplatelet therapy in coronary artery disease developed in collaboration with EACTS

Marco Valgimigli, Héctor Bueno, Robert A. Byrne, Jean-Philippe Collet, more

Revista Espa�ola de Cardiolog�a (English Edition) > 2018 > 71 > 1 > 42

article

Observational Study of Platelet Reactivity in Patients Presenting With ST-Segment Elevation Myocardial Infarction Due to Coronary Stent Thrombosis Undergoing Primary Percutaneous Coronary Intervention

Thea C. Godschalk, Robert A. Byrne, Tom Adriaenssens, Nikesh Malik, more

JACC: Cardiovascular Interventions > 2017 > 10 > 24 > 2548-2556

High platelet reactivity (HPR) was studied in patients presenting with ST-segment elevation myocardial infarction (STEMI) due to stent thrombosis (ST) undergoing immediate percutaneous coronary intervention (PCI).HPR on P2Y₁₂ inhibitors (HPR-ADP) is frequently observed in stable patients who have experienced ST. The HPR rates in patients presenting with ST for immediate PCI are unknown.Consecutive...

article

Transfemoral Approach for Coronary Angiography and Intervention

Abdulla A. Damluji, Daniel W. Nelson, Marco Valgimigli, Stephan Windecker, more

JACC: Cardiovascular Interventions > 2017 > 10 > 22 > 2269-2279

The aim of this study was to examine the current practice and use of transfemoral approach (TFA) for coronary angiography and intervention.Wide variability exists in TFA techniques for coronary procedures.The authors developed a survey instrument that was distributed via e-mail lists from professional societies to interventional cardiologists from 88 countries between March and December 2016.Of 987...

article

Mechanisms of Very Late Bioresorbable Scaffold Thrombosis

Kyohei Yamaji, Yasushi Ueki, Geraud Souteyrand, Joost Daemen, more

Journal of the American College of Cardiology > 2017 > 70 > 19 > 2330-2344

Very late scaffold thrombosis (VLScT) occurs more frequently after bioresorbable scaffold (Absorb BVS 1.1, Abbott Vascular, Santa Clara, California) implantation than with metallic everolimus-eluting stents.The purpose of this study was to elucidate mechanisms underlying VLScT as assessed by optical coherence tomography (OCT).The INVEST (Independent OCT Registry on Very Late Bioresorbable Scaffold...

article

Biodegradable polymer drug-eluting stents: caveat emptor

Robert A Byrne, Tibor Schuster

The Lancet > 2017 > 390 > 10105 > 1814-1816

article

Coronary balloon angioplasty, stents, and scaffolds

Robert A Byrne, Gregg W Stone, John Ormiston, Adnan Kastrati

The Lancet > 2017 > 390 > 10096 > 781-792

Since the first coronary angioplasty on Sept 16, 1977, the field of percutaneous coronary intervention has evolved rapidly. Now marking its 40th anniversary, percutaneous coronary intervention has become one of the most common medical procedures worldwide. Much of this progress has been due to the iteration and improvement of angioplasty technologies. Balloon angioplasty was limited by unpredictable...

article

Neointimal Modification With Scoring Balloon and Efficacy of Drug-Coated Balloon Therapy in Patients With Restenosis in Drug-Eluting Coronary Stents

Sebastian Kufner, Michael Joner, Simon Schneider, Ralph Tölg, more

JACC: Cardiovascular Interventions > 2017 > 10 > 13 > 1332-1340

The aim of this study was to compare neointimal modification with scoring balloon pre-dilation before drug-coated balloon (DCB) versus DCB standard therapy in patients presenting with drug-eluting stent (DES) restenosis.DCB angioplasty for the treatment of coronary drug-eluting stent restenosis has demonstrated encouraging results. The efficacy of DCB treatment relies on rapid initial drug transfer...

article

Arterial Remodeling After Bioresorbable Scaffolds and Metallic Stents

Patrick W. Serruys, Yuki Katagiri, Yohei Sotomi, Yaping Zeng, more

Journal of the American College of Cardiology > 2017 > 70 > 1 > 60-74

Although previous observational studies have documented late luminal enlargement and expansive remodeling following implantation of a bioresorbable vascular scaffold (BVS), no comparison with metallic stents has been conducted in a randomized fashion.This study sought to compare vessel remodeling patterns after either Absorb BVS or Xience metallic drug-eluting stent (DES) implantation (Abbott Vascular,...

article

Long-Term Clinical Outcomes of Patients Treated With Everolimus-Eluting Bioresorbable Stents in Routine Practice

Jens Wiebe, Petra Hoppmann, Roisin Colleran, Sebastian Kufner, more

JACC: Cardiovascular Interventions > 2017 > 10 > 12 > 1222-1229

The aim of this study was to report clinical outcomes in patients treated in routine practice 2 years after everolimus-eluting bioresorbable stent (BRS) implantation.Long-term results in patients undergoing BRS implantation in routine clinical practice are sparse, and existing evidence from randomized trials considers mostly selected patients.The ISAR-ABSORB registry enrolled consecutive patients...

article

Markedly different tissue types on optical coherence tomography imaging in a patient with multiple lesion drug‐eluting stent in‐stent restenosis

Tobias A. Rheude, Erion Xhepa, Robert A. Byrne

Catheterization and Cardiovascular Interventions > 89 > 6 > E181 - E184

The treatment of in‐stent restenosis after drug‐eluting stent (DES) implantation remains a major clinical challenge. Optical coherence tomography (OCT) imaging at the time of presentation can provide important information on mechanical factors contributing to stent failure as well as on tissue characteristics of the in‐stent neointimal tissue. We report a case of markedly different tissue types—characterized...

article

Reduced duration of dual antiplatelet therapy using an improved drug-eluting stent for percutaneous coronary intervention of the left main artery in a real-world, all-comer population: Rationale and study design of the prospective randomized multicenter IDEAL-LM trial

Miguel E. Lemmert, Keith Oldroyd, Paul Barragan, Maciej Lesiak, more

American Heart Journal > 2017 > 187 > C > 104-111

Continuous improvements in stent technology make percutaneous coronary intervention (PCI) a potential alternative to surgery in selected patients with unprotected left main coronary artery (uLMCA) disease. The optimal duration of dual antiplatelet therapy (DAPT) in these patients remains undetermined, and in addition, new stent designs using a bioabsorbable polymer might allow shorter duration of...

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INFONA - science communication portal

Search results for: Robert A. Byrne

A prospective trial of a novel low‐dose paclitaxel‐coated balloon therapy in patients with restenosis in drug‐eluting coronary stents Intracoronary Stenting and Angiographic Results: Optimizing Treatment of Drug Eluting Stent In‐stent REstenosis 3A (ISAR‐DESIRE 3A)

Angiographic performance of everolimus‐eluting stents for the treatment of coronary in‐stent restenosis in daily practice

Efficacy of drug‐coated balloon angioplasty in early versus late occurring drug‐eluting stent restenosis: A pooled analysis from the randomized ISAR DESIRE 3 and DESIRE 4 trials

Outcome after new generation single‐layer polytetrafluoroethylene‐covered stent implantation for the treatment of coronary artery perforation

Qualitative and quantitative neointimal characterization by optical coherence tomography in patients presenting with in-stent restenosis

Incidence and predictors of reCurrent restenosis after drug-coated balloon Angioplasty for Restenosis of a drUg-eluting Stent: The ICARUS Cooperation

Neoatherosclerosis in Patients With Coronary Stent Thrombosis

Randomised comparison of vascular response to biodegradable polymer sirolimus eluting and permanent polymer everolimus eluting stents: An optical coherence tomography study

Comparative efficacy of two paclitaxel-coated balloons with different excipient coatings in patients with coronary in-stent restenosis

Special article 2017 ESC focused update on dual antiplatelet therapy in coronary artery disease developed in collaboration with EACTS

Observational Study of Platelet Reactivity in Patients Presenting With ST-Segment Elevation Myocardial Infarction Due to Coronary Stent Thrombosis Undergoing Primary Percutaneous Coronary Intervention

Transfemoral Approach for Coronary Angiography and Intervention

Mechanisms of Very Late Bioresorbable Scaffold Thrombosis

Biodegradable polymer drug-eluting stents: caveat emptor

Coronary balloon angioplasty, stents, and scaffolds

Neointimal Modification With Scoring Balloon and Efficacy of Drug-Coated Balloon Therapy in Patients With Restenosis in Drug-Eluting Coronary Stents

Arterial Remodeling After Bioresorbable Scaffolds and Metallic Stents

Long-Term Clinical Outcomes of Patients Treated With Everolimus-Eluting Bioresorbable Stents in Routine Practice

Markedly different tissue types on optical coherence tomography imaging in a patient with multiple lesion drug‐eluting stent in‐stent restenosis

Reduced duration of dual antiplatelet therapy using an improved drug-eluting stent for percutaneous coronary intervention of the left main artery in a real-world, all-comer population: Rationale and study design of the prospective randomized multicenter IDEAL-LM trial

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