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Twelve alkyl analogues (1–12) of the high‐affinity serotonin transporter (SERT) inhibitor 6‐nitroquipazine (6‐NQ) were synthesized and studied using in vitro radioligand competition binding assays to determine their binding affinity (Ki). The putative antidepressant activity of five of the binders with the highest SERT binding affinities was studied by the forced swim and locomotor activity mouse...
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