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Objective To test the hypotheses that (1) CYP2D6 genotype is associated with pharmacokinetics of ophthalmic timolol and (2) variation in genotypes of ADRB1 (β1-adrenoceptor) and GNAS1 (α-subunit of G-protein) modulate heart rate (HR), and systolic (SAP) and diastolic (DAP) arterial pressure responses to timolol. Methods Nineteen glaucoma patients and eighteen healthy volunteers were treated with...
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