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Transition metal ions are served as disinfectant thousand years ago. However, the in vivo antibacterial application of metal ions is strongly restricted due to its high affinity with proteins and lack of appropriate bacterial targeting method. Herein, for the first time, Zn2+‐gallic acid nanoflowers (ZGNFs) are synthesized by a facile one‐pot method without additional stabilizing agents. ZGNFs are...
Drug resistance in pathogenic bacteria has become a major threat to global health. The misuse of antibiotics has increased the number of resistant bacteria in the absence of rapid, accurate, and cost‐effective diagnostic tools. Here, an amplification‐free CRISPR‐Cas12a time‐resolved fluorescence immunochromatographic assay (AFC‐TRFIA) is used to detect drug‐resistant Salmonella. Multi‐locus targeting...
Mitochondria, which are important mediators for cancer initiation, growth, metastasis, and drug resistance, have been considered as a major target in cancer therapy. Herein, an acid‐activated mitochondria‐targeted drug nanocarrier is constructed for precise delivery of nitric oxide (NO) as an adenosine triphosphate (ATP) suppressor to amplify the therapeutic efficacy in cancer treatments. By combining...
Endophthalmitis, derived from the infections of pathogens, is a common complication during the use of ophthalmology‐related biomaterials and after ophthalmic surgery. Herein, aiming at efficient photodynamic therapy (PDT) of bacterial infections and biofilm eradication of endophthalmitis, a pH‐responsive zeolitic imidazolate framework‐8‐polyacrylic acid (ZIF‐8‐PAA) material is constructed for bacterial...
Although many approaches have been developed to encapsulate functional species into polyelectrolyte films, few of them can effectively control the final distribution of these ones. Herein, a facile strategy is proposed to spatially control the encapsulation of guest species by locally regulating the structural transformation of polyelectrolyte films. Patterned porosity is created within a film by...
In article number 1804867, Ke‐Feng Ren, Jian Ji, and co‐workers propose a facile strategy to spatially control the encapsulation of guest species by locally regulating the structural transformation of polyelectrolyte films. Various guest species can be locally encapsulated into the film, forming distinct patterns of arbitrary shapes and sizes.
Complete drug release and efficient drug retention are two critical factors in reversing drug resistance in cancer therapy. In this regard, polymeric micelles with an upper critical solution temperature (UCST) are designed as a new exploration to reverse drug resistance. The amphiphilic UCST‐type block copolymers are used to encapsulate photothermal agent IR780 and doxorubicin (DOX) simultaneously...
A glutathione (GSH) activatable photosensitizer‐conjugated pseudopolyrotaxane nanocarrier is fabricated as a new photodynamic theranostic platform by Q. Jin, J. Ji, and co‐workers on page 6223. The nanocarriers exhibit a GSH activated fluorescence signal and phototoxicity for PDT (photodynamic therapy). After being internalized by cancer cells, the high concentration of GSH triggers the release and...
Photodynamic theranostics has recently been extensively explored as a promising approach for precise localization and therapy. Herein, glutathione (GSH) activatable photosensitizer (PS)‐conjugated pseudopolyrotaxane nanocarriers (α‐CD‐ss‐Ce6 NPs) are reported for enhanced photodynamic theranostics by taking advantage of the noncovalent interactions between α‐cyclodextrin (α‐CD) and poly(ethylene glycol)...
An intracellular dual fluorescent light‐up bioprobe with aggregation‐induced emission features and endogenously producing photosensitizer protoporphyrin IX (PpIX) abilities is designed and synthesized. The bioprobe is nonemissive in physiological environment. However, the bioprobe can selectively light up cancer cells with blue fluorescence of tetraphenylene (TPE) and red fluorescence of PpIX, owing...
Despite the exciting advances in cancer chemotherapy over past decades, drug resistance in cancer treatment remains one of the primary reasons for therapeutic failure. IR‐780 loaded pH‐responsive polymeric prodrug micelles with near infrared (NIR) photothermal effect are developed to circumvent the drug resistance in cancer treatment. The polymeric prodrug micelles are stable in physiological environment,...
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