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A series of four novel hydrazine-modified diamine conjugates (7a-b, 8a-b) were synthesized and evaluated for cytotoxicity against Melanoma B16, α-difluoromethylornithine (DFMO)-treated B16, spermidine (SPD)-treated B16, Mouse leukemia L1210 and Hela cell lines. Both the DFMO-B16 and SPD-B16 experiments indicated that conjugates 7a-b and 8a-b could recognize the polyamine transporter (PAT) and enter...
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