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Daptomycin is a cyclic anionic lipopeptide with an antibiotic activity that is completely dependent on the presence of calcium (as Ca 2+ ). In a previous study [Jung et al., 2004. Chem. Biol. 11, 949–957], it was concluded that daptomycin underwent two Ca 2+ -dependent structural transitions, whereby the first transition was solely dependent on Ca 2+ , while the second transition...
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