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Objective
Spreading depolarization (SD) is a transient self‐propagating wave of neuronal and glial depolarization coupled with large membrane ionic changes and a subsequent depression of neuronal activity. Spreading depolarization in the cortex is implicated in migraine, stroke, and epilepsy. Conversely, spreading depolarization in the striatum, a brain structure deeply involved in motor control...
Background
Here we aimed to evaluate: (1) Rhes mRNA expression in mouse midbrain, (2) the effect of Rhes deletion on the number of dopamine neurons, (3) nigrostriatal‐sensitive behavior during aging in knockout mice.
Methods
Radioactive in situ hybridization was assessed in adult mice. The beam‐walking test was executed in 3‐, 6‐ and 12‐month‐old mice. Immunohistochemistry of midbrain tyrosine...
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