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The ability of the opioid receptor antagonist naloxone to potentiate the effects of subeffective doses of chlordiazepoxide, diazepam and buspirone was evaluated in Swiss mice tested in an elevated plus maze. Diazepam (0.5 mg/kg), chlordiazepoxide (2.5 mg/kg) and buspirone (2 mg/kg) were ineffective per se but, when combined with naloxone (10 mg/kg), they increased the proportion of open arm entries...
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