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Neuronal granules play an important role in the localization and transport of translationally silenced messenger ribonucleoproteins in neurons. Among the factors associated with these granules, the RNA‐binding protein G3BP1 (stress‐granules assembly factor) is involved in neuronal plasticity and is induced in Alzheimer's disease. We immunopurified a stable complex containing G3BP1 from mouse brain...
Ras‐GAP SH3‐domain–binding protein, G3BP, is an important component in the assembly of stress granules (SGs), which are cytoplasmic aggregates assembled following translational stress. To assess the physiological function of G3BP, we generated viable G3bp1‐knockout (KO) mice, which demonstrated behavioral defects linked to the CNS‐associated with ataxia phenotype. Immunohistochemistry pinpointed high...
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