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ShcA is an adaptor protein that binds to tyrosine kinase receptors. Its germ line deletion is embryonic lethal with abnormal cardiovascular system formation. We used the Cre-loxP technology and the smooth muscle protein-22 (Sm22) cre transgene, to ablate ShcA specifically in the cardiovascular system from early embryonic development. Conditionally mutant mice developed signs of severe dilated cardiomyopathy,...
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