Search results for: Marcus A. Koch
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Protein structure similarity clustering and natural product structure as guiding principles in drug discovery
Drug Discovery Today > 2005 > 10 > 7 > 471-483
The identification of new chemical entities that are capable of altering protein function lies at the heart of the hit and lead finding process, for which combinatorial chemistry has emerged as a powerful tool. Following the maturation of combinatorial chemistry and compound library development, it was soon recognized that biological relevance, design and diversity of a library are more important...
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