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BackgroundAsthma is a heterogenetic disorder characterized by chronic inflammation with variable airflow obstruction and airway hyper‐responsiveness. As the most potent and popular bronchodilators, β2 adrenergic receptor (β2AR) agonists bind to the β2ARs that are coupled via a stimulatory G protein to adenylyl cyclase, thereby improving cAMP accumulation and resulting in airway smooth muscle relaxation...
BackgroundPrevious studies have shown the relationship between club cell secretory protein (Clara) (CC‐16) and respiratory diseases. However, few studies have explored the associations between urine CC‐16 levels and environmental tobacco smoke (ETS) exposure in children. The objective of this study was to evaluate whether ETS exposure is associated with CC‐16 when stratified by asthma status.
MethodsIn...
BackgroundEosinophils and their products, including leukotrienes and eosinophil cationic protein (ECP), are well‐known mediators of inflammation and tissue damage in asthma. The antimicrobial peptide LL‐37 exhibits a variety of immunomodulatory activities. However, the role of LL‐37 in asthma has not been fully addressed. Here, we aim to investigate the effect of LL‐37 on inducing inflammatory mediators...
BackgroundHuman induced pluripotent stem cells (iPSCs) possess remarkable self‐renewal capacity and the potential to differentiate into novel cell types, such as mesenchymal stem cells (MSCs). iPSC‐MSCs have been shown to enhance tissue regeneration and attenuate tissue ischaemia; however, their contribution to the immune regulation of Th2‐skewed allergic rhinitis (AR) and asthma remains unclear....
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