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Objective Information is lacking on whether the CYP3A5 genotype affects the disposition and effects of midazolam during the long-term intensive care sedation of patients. This study was undertaken to estimate whether the CYP3A5 genotype can explain a relevant portion of pharmacokinetic interindividual variability. Methods We determined the CYP3A5 genotype in 71 Caucasian patients who underwent long-term...
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