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The production and secretion of peptides by adrenocortical tumors have not been well studied. We therefore studied the production and secretion of two vasoactive peptides, adrenomedullin and endothelin-1 in SW-13 human adrenocortical carcinoma cells by radioimmunoassay and Northern blot analysis. Both immunoreactive-adrenomedullin and immunoreactive-endothelin were detected in the culture medium of...
Sone, M., K. Takahashi, F. Satoh, O. Murakami, K. Totsune, M. Ohneda, H. Sasano, H. Ito and T. Mouri.Specific adrenomedullin binding sites in the human brain. Peptides 18(8) 1125-1129, 1997.-Binding sites for adrenomedullin in human brain were investigated and characterized by radioligand binding. Specific binding sites for adrenomedullin were present in every region of human brain (cerebral cortex,...
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