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L‐dopa induced dyskinesias (LIDs) are a disabling motor complication of L‐dopa therapy for Parkinson's disease (PD) management. Treatment options remain limited and the underlying network mechanisms remain unclear due to a complex pathophysiology. What is well‐known, however, is that aberrant striatal signaling plays a key role in LIDs development. Here, we discuss the specific contribution of striatal...
Background
Dyskinesias are a disabling motor complication that arises with prolonged l‐dopa treatment. Studies using D1 receptor drugs and genetically modified mice suggest that medium spiny neurons expressing D1 receptors play a primary role in l‐dopa–induced dyskinesias. However, the specific role of these neurons in dyskinesias is not fully understood.
Methods
We used optogenetics, which allows...
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