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A series of arylsulfonamide derivatives of (aryloxy)ethyl pyrrolidines and piperidines was synthesized to develop new α1-adrenoceptor antagonists with uroselective profile. Biological evaluation for α1- and α2-adrenorecepor showed that tested compounds 13–37 displayed high-to-moderate affinity for the α1-adrenoceptor (Ki=34–348nM) and moderate selectivity over α2-receptor subtype. Compounds with highest...
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