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To explore whether DNA polymerase beta (pol β) contributes to the malignant transformation of gastric mucosa, we examined pol β in gastric tumor cell lines, primary tumors and precancerous lesions. Point mutations of pol β were detected in 6 of 13 cell lines and 23 of 104 tissues including 35.0% (14/40) of gastric cancer (GC), 30.0% (3/10) of dysplasia (Dys), 28.6% (4/14) of intestinal metaplasia...
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