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Background
Our previous report has shown that the flavonoid 2′‐hydroxyflavanone (2′‐HF) showed inhibition of androgen receptor (AR) activity against androgen‐sensitive prostate cancer (PCa) cells, LNCaP, and exhibited antitumor effects against androgen‐insensitive PCa cells, PC‐3, and DU145. In the present study, we prepared a derivative of 2′‐HF, 16MS7F1924, and confirmed the effects of this derivative...
Apoptosis is an important mechanism of physiological and pathological cell death and is known to occur in various neurological disorders. Apoptosis is associated with activation of genetic programs in which apoptosis-effector genes promote cell death, thereby opposing repressor genes that enhance cell survival. In this review, we describe various apoptotic pathways, with a special reference to the...
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