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Our previous study showed that IL-2 and IL-7 could mutually enhance the immunogenicity of canine parvovirus VP2 DNA vaccine, although the underlying mechanism remained unknown. Here, we used the OVA gene as a DNA vaccine in a mouse model to test their enhancement on DNA vaccine immunogenicity and to explore the molecular mechanism. Results showed that both IL-2 and IL-7 genes significantly increased...
The potent mucosal adjuvant properties of the type II heat-labile enterotoxin LT-IIa of Escherichia coli are dependent upon binding of the B pentamer of the enterotoxin (LT-IIa-B 5 ) to ganglioside receptors on immunocompetent cells. To evaluate the immunomodulatory activities of LT-IIa-B 5 , in vitro experiments employing bone marrow-derived dendritic cells (BMDC) were performed....
The pentameric B subunit of the Escherichia coli LT-IIb enterotoxin (LT-IIb-B 5 ) activates TLR2 signaling in macrophages. Herein we demonstrate that LT-IIb-B 5 , in contrast to a TLR2-nonbinding point mutant, induces functional activation of bone marrow-derived dendritic cells and stimulates CD4 + T cell proliferation, activities which suggested that LT-IIb-B 5 might...
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