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The presenilin (PS)-dependent γ-secretase activity refers to a high molecular mass-complex including, besides PS1 or PS2, three other proteins recently identified, namely nicastrin, Aph-1, and Pen-2. This proteolytic complex has been shown to contribute to both γ- and ε-cleavages of the β-amyloid precursor protein (βAPP), thereby generating β-amyloid peptides (Aβ) and the APP intracellular domain...
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