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Summary
A microRNA (abbreviated miRNA) is a small non‐coding RNA molecule (containing about 22 nucleotides) that functions in RNA silencing and post‐transcriptional regulation of gene expression. miRNAs derive from regions of RNA transcripts that fold back on themselves to form short hairpins and resemble the small interfering RNAs (siRNAs) of the RNA interference (RNAi) pathway. The human genome...
Purpose To examine the effect of intraocularly produced glucagon‐like peptide‐1 (GLP‐1) on the survival rate of retinal ganglion cells in an optic nerve crush model.
Methods Forty‐one Sprague‐Dawley rats were divided into a study group (21 animals) in which 4 beads with 3000 genetically modified cells to produce GLP‐1 were intravitreally implanted into the right eye; a saline control group (n=12)...
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