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Cancer Stem Cells
In article number 2200364, Zhuo Xiong and co‐workers report that 3D bioprinted GelMA‐nanoclay hybrid hydrogels can induce and enrich colorectal cancer stem cells (CSCs) by promoting the formation of spheroids by activating Wnt/β‐catenin signaling. These spheroids can be isolated easily and are promising CSC enrichment models with increased stemness, high consistency, yield and efficiency...
Cancer stem cells (CSCs) are a rare cell population in tumors that are responsible for tumor recurrence and metastasis. They are a priority as therapeutic targets, however, assays targeting CSCs have been limited by expanding and maintaining CSCs in vitro. Here, the authors find that gelatin methacryloyl (GelMA)‐nanoclay hybrid hydrogels can induce and enrich colorectal CSCs assisted by three‐dimensional...