Search results for: Dong Chang

Items from 1 to 20 out of 223 results

article

BN‐Isosteres of Nonacene with Antiaromatic B₂C₄ and N₂C₄ Heterocycles: Synthesis and Strong Luminescence**

Cheng Chen, Zhi‐Dong Chang, Yong‐Kang Guo, Yan‐Bo Huang, more

Angewandte Chemie International Edition > 63 > 11 > n/a - n/a

Embedding both boron and nitrogen into the backbone of acenes to generate their isoelectronic structures has significantly enriched the acene chemistry to offer appealing properties. However, only small BN‐heteroacenes have been extensively investigated, with BN‐heptacenes as the hitherto longest homologue. Herein, we report the synthesis of three new nonacene BN‐isosteres via incorporating a pair...

article

BN‐Isosteres of Nonacene with Antiaromatic B₂C₄ and N₂C₄ Heterocycles: Synthesis and Strong Luminescence**

Cheng Chen, Zhi‐Dong Chang, Yong‐Kang Guo, Yan‐Bo Huang, more

Angewandte Chemie > 136 > 11 > n/a - n/a

article

Single‐cell phenotyping of bacteria combined with deep sequencing for improved contextualization of microbiome analyses

Lisa Budzinski, Victoria Goetze, Hyun‐Dong Chang

European Journal of Immunology > 54 > 1 > n/a - n/a

Great effort was made to characterize the bacterial communities inhabiting the human body as a factor in disease, resulting in the realization that a wide spectrum of diseases is associated with an altered composition of the microbiome. However, the identification of disease‐relevant bacteria has been hindered by the high cross‐sectional diversity of individual microbiomes, and in most cases, it remains...

article

New Monoterpenoid Indole Hybrids from Gelsemium elegans with Anti‐Inflammatory and Osteoclast Inhibitory Activities

Pan‐Pan Zhang, Jia‐Jun Liang, Qing‐Yu Lu, Xin Yin, more

Chemistry & Biodiversity > 20 > 12 > n/a - n/a

Gelsegansymines A (1) and B (2), two new indole alkaloids along with six known analogues (3–8) were isolated from the aerial parts of Gelsemium elegans. Their structures were elucidated by means of spectroscopic techniques. Structurally, compounds 1 and 2 possessed the rare cage‐like gelsedine skeleton hybrid with bicyclic monoterpenoid. The anti‐inflammatory activities of isolated compounds (1–3)...

article

Chinese expert consensus on the construction of the fluoroless cardiac electrophysiology laboratory and related techniques

Chenyang Jiang, Changsheng Ma, Songwen Chen, Shiquan Chen, more

Pacing and Clinical Electrophysiology > 46 > 9 > 1035 - 1048

Transcatheter radiofrequency ablation has been widely introduced for the treatment of tachyarrhythmias. The demand for catheter ablation continues to grow rapidly as the level of recommendation for catheter ablation. Traditional catheter ablation is performed under the guidance of X‐rays. X‐rays can help display the heart contour and catheter position, but the radiobiological effects caused by ionizing...

article

Rapid detection and online analysis of microbial changes through flow cytometry

Jonas Kupschus, Stefan Janssen, Andreas Hoek, Jan Kuska, more

Cytometry Part A > 103 > 5 > 419 - 428

Short‐read 16 S rRNA gene sequencing is the dominating technology to profile microbial communities in different habitats. Its uncontested taxonomic resolution paved the way for major contributions to the field. Sample measurement and analysis, that is, sequencing, is rather slow–in order of days. Alternatively, flow cytometry can be used to profile the microbiota of various sources within a few minutes...

article

Molecular mechanisms underlying the toxicity and detoxification of trace metals and metalloids in plants

Zhong Tang, Han‐Qing Wang, Jie Chen, Jia‐Dong Chang, more

Journal of Integrative Plant Biology > 65 > 2 > 570 - 593

Plants take up a wide range of trace metals/metalloids (hereinafter referred to as trace metals) from the soil, some of which are essential but become toxic at high concentrations (e.g., Cu, Zn, Ni, Co), while others are non‐essential and toxic even at relatively low concentrations (e.g., As, Cd, Cr, Pb, and Hg). Soil contamination of trace metals is an increasing problem worldwide due to intensifying...

article

Rethinking ‘immunological memory’: Local and systemic immunity provided by bone marrow‐resident memory cells

Mairi Anne McGrath, Jun Dong, Mir‐Farzin Mashreghi, Hyun‐Dong Chang, more

Scandinavian Journal of Immunology > 96 > 6 > n/a - n/a

It has been 25 years since we first described long‐lived memory plasma cells of the bone marrow, 13 years since we identified bone marrow resident memory T cells and 2 years since we showed that the bone marrow is also a preferred location of resident memory B cells. The bone marrow is increasingly recognized as a fundamental component of long‐lasting immunological memory, not only providing protective...

article

Is left ventricular septal pacing enough clinically, or must left bundle branch be captured absolutely?

Kailun Zhu, Dong Chang, Linlin Li, Jianghai Liu, more

Journal of Cardiovascular Electrophysiology > 33 > 10 > 2233 - 2233

article

Resident memory CD4⁺ T lymphocytes mobilize from bone marrow to contribute to a systemic secondary immune reaction

Carla Cendón, Weijie Du, Pawel Durek, Yuk‐Chien Liu, more

European Journal of Immunology > 52 > 5 > 737 - 752

Resident memory T lymphocytes (T_RM) of epithelial tissues and the Bm protect their host tissue. To what extent these cells are mobilized and contribute to systemic immune reactions is less clear. Here, we show that in secondary immune reactions to the measles‐mumps‐rubella (MMR) vaccine, CD4⁺ T_RM are mobilized into the blood within 16 to 48 h after immunization in humans. This mobilization of T_RM...

article

Mass cytometry‐based identification of a unique T‐cell signature in childhood allergic asthma

Hartmann Raifer, Axel R. Schulz, Johanna Theodorou, Addi J. Romero‐Olmedo, more

Allergy > 77 > 1 > 313 - 316

article

Guidelines for the use of flow cytometry and cell sorting in immunological studies (third edition)

Andrea Cossarizza, Hyun‐Dong Chang, Andreas Radbruch, Sergio Abrignani, more

European Journal of Immunology > 51 > 12 > 2708 - 3145

The third edition of Flow Cytometry Guidelines provides the key aspects to consider when performing flow cytometry experiments and includes comprehensive sections describing phenotypes and functional assays of all major human and murine immune cell subsets. Notably, the Guidelines contain helpful tables highlighting phenotypes and key differences between human and murine cells. Another useful feature...

article

One‐step electrodeposition preparation of polyaniline/f‐MWCNTs as electrochemical sensors for detection of 10‐hydroxycamptothecine

Lingqiang Meng, Jianmin Dai, Shengzhong Rong, Hongmin Gao, more

Biotechnology and Applied Biochemistry > 68 > 6 > 1192 - 1201

In our work, one‐step electro‐deposition method was adopted to produce polyaniline (PANI) and functional multiwalled carbon nanotubes (f‐MWCNTs) films on glass carbon electrodes, and the modified electrodes were applied as an electrochemical sensor for determination of 10‐hydroxycamptothecine (10‐HCPT). The f‐MWCNTs were handled by ultrasound processing in concentrated oxidizing acid solution, which...

article

Maintenance of quiescent immune memory in the bone marrow

Hyun‐Dong Chang, Andreas Radbruch

European Journal of Immunology > 51 > 7 > 1592 - 1601

The adaptive immune system has the important ability to generate and maintain a memory for antigens once encountered. Recent progress in understanding the organization of immunological memory has challenged the established paradigm of maintenance of memory by restless, circulating, and “homeostatically” proliferating lymphocytes. Among other tissues, the bone marrow has emerged as a preferred resting...

article

Left atrial thickness and acute thermal injury in patients undergoing ablation for atrial fibrillation: Laser versus radiofrequency energies

Xu Gao, Dong Chang, Kenneth C. Bilchick, Sarah K. Hussain, more

Journal of Cardiovascular Electrophysiology > 32 > 5 > 1259 - 1267

Introduction Thermally induced cardiac lesions result in necrosis, edema, and inflammation. This tissue change may be seen with ultrasound. In this study, we sought to use intracardiac echocardiography (ICE) to evaluate pulmonary vein tissue morphology and assess the acute tissue changes that occur following radiofrequency (RF) or laser ablation for atrial fibrillation (AF). Methods and Results...

article

Antigen‐driven PD‐1⁺TOX⁺BHLHE40⁺ and PD‐1⁺TOX⁺EOMES⁺ T lymphocytes regulate juvenile idiopathic arthritis in situ

Patrick Maschmeyer, Gitta Anne Heinz, Christopher Mark Skopnik, Lisanne Lutter, more

European Journal of Immunology > 51 > 4 > 915 - 929

T lymphocytes accumulate in inflamed tissues of patients with chronic inflammatory diseases (CIDs) and express pro‐inflammatory cytokines upon re‐stimulation in vitro. Further, a significant genetic linkage to MHC genes suggests that T lymphocytes play an important role in the pathogenesis of CIDs including juvenile idiopathic arthritis (JIA). However, the functions of T lymphocytes in established...

article

Deep phenotypical characterization of human CD3⁺CD56⁺ T cells by mass cytometry

Addi J. Romero‐Olmedo, Axel R. Schulz, Magdalena Huber, Corinna U. Brehm, more

European Journal of Immunology > 51 > 3 > 672 - 681

CD56⁺ T cells are a group of pro‐inflammatory CD3⁺ lymphocytes with characteristics of natural killer cells, being involved in antimicrobial immune defense. Here, we performed deep phenotypic profiling of CD3⁺CD56⁺ cells in peripheral blood of normal human donors and individuals sensitized to birch‐pollen or/and house dust mite by high‐dimensional mass cytometry combined with manual and computational...

article

OsNRAMP1 transporter contributes to cadmium and manganese uptake in rice

Jia‐Dong Chang, Sheng Huang, Naoki Yamaji, Wenwen Zhang, more

Plant, Cell & Environment > 43 > 10 > 2476 - 2491

Rice is a major dietary source of the toxic metal, cadmium (Cd). Previous studies reported that the rice transporter, OsNRAMP1, (Natural resistance‐associated macrophage protein 1) could transport iron (Fe), Cd and arsenic (As) in heterologous yeast assays. However, the in planta function of OsNRAMP1 remains unknown. Here, we showed that OsNRAMP1 was able to transport Cd and manganese (Mn) when expressed...

article

Atrioesophageal fistula post atrial fibrillation ablation: A multicenter study from China

Chang‐Yi Li, Song‐Nan Li, Chen‐Yang Jiang, Hua Fu, more

Pacing and Clinical Electrophysiology > 43 > 7 > 627 - 632

Background and objective Atrioesophageal fistula (AEF) is a rare but devastating complication with high mortality post atrial fibrillation (AF) ablation. The purpose of current study was to determine the epidemiology, clinical features, pathogenesis, and management of AEF after AF ablation. Methods and results Patients with diagnosed AEF were included and retrospectively analyzed according to the...

article

Microorganisms and Their Activities Within Microbial Communities

Susann Müller, Hyun‐Dong Chang

Cytometry Part A > 97 > 7 > 681 - 682

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INFONA - science communication portal

Search results for: Dong Chang

BN‐Isosteres of Nonacene with Antiaromatic B₂C₄ and N₂C₄ Heterocycles: Synthesis and Strong Luminescence**

BN‐Isosteres of Nonacene with Antiaromatic B₂C₄ and N₂C₄ Heterocycles: Synthesis and Strong Luminescence**

Single‐cell phenotyping of bacteria combined with deep sequencing for improved contextualization of microbiome analyses

New Monoterpenoid Indole Hybrids from Gelsemium elegans with Anti‐Inflammatory and Osteoclast Inhibitory Activities

Chinese expert consensus on the construction of the fluoroless cardiac electrophysiology laboratory and related techniques

Rapid detection and online analysis of microbial changes through flow cytometry

Molecular mechanisms underlying the toxicity and detoxification of trace metals and metalloids in plants

Rethinking ‘immunological memory’: Local and systemic immunity provided by bone marrow‐resident memory cells

Is left ventricular septal pacing enough clinically, or must left bundle branch be captured absolutely?

Resident memory CD4⁺ T lymphocytes mobilize from bone marrow to contribute to a systemic secondary immune reaction

Mass cytometry‐based identification of a unique T‐cell signature in childhood allergic asthma

Guidelines for the use of flow cytometry and cell sorting in immunological studies (third edition)

One‐step electrodeposition preparation of polyaniline/f‐MWCNTs as electrochemical sensors for detection of 10‐hydroxycamptothecine

Maintenance of quiescent immune memory in the bone marrow

Left atrial thickness and acute thermal injury in patients undergoing ablation for atrial fibrillation: Laser versus radiofrequency energies

Antigen‐driven PD‐1⁺TOX⁺BHLHE40⁺ and PD‐1⁺TOX⁺EOMES⁺ T lymphocytes regulate juvenile idiopathic arthritis in situ

Deep phenotypical characterization of human CD3⁺CD56⁺ T cells by mass cytometry

OsNRAMP1 transporter contributes to cadmium and manganese uptake in rice

Atrioesophageal fistula post atrial fibrillation ablation: A multicenter study from China

Microorganisms and Their Activities Within Microbial Communities

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