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Simultaneous PET/MRI shows great promise for improved detection and diagnosis of disease. Commercially available whole body combined PET/MRI systems are currently prohibitively expensive, limiting access to the technology. MRI-compatible PET inserts present a lower-cost alternative, adding PET capabilities to existing MRI installations. A brain sized radio-frequency (RF)-penetrable PET insert has...
Integrated PET/MRI enables simultaneous measurement of molecular, functional and anatomical information of the body in one combined scan, providing physicians and researchers with multi-parameter information. However, the long-term impact of integrated PET/MRI is limited by the high cost of the current commercial systems, which require the users to purchase both PET and MR subsystems, which are permanently...
Combined positron emission tomography (PET) and magnetic resonance imaging (MRI) has shown potential to provide a powerful tool for disease characterization as it enables the simultaneous measurement of molecular, functional and anatomical information of the body. However, the availability of whole-body simultaneous PET/MRI has been limited by its high cost. To address this issue, we have developed...
The combination of PET's high sensitivity for visualizing and quantifying molecular signatures and MRI's exquisite anatomical soft tissue contrast holds great promise for improving diagnosis and characterization of disease. However, the prohibitively high cost of integrated clinical PET/MRI systems presents a significant barrier to entry for simultaneous PET/MRI imaging studies. To address this problem,...
Reducing the number of readout channels of PET detectors with multiplexing can save the cost and complexity for developing a scanner. However, a high multiplexing ratio can also degrade the signal-to-noise (SNR) ratio of the detector since the noise of the multiplexed channels is summed together. Compressed sensing (CS) was recently shown to be a promising multiplexing method for PET detectors that...
Positron emission tomography (PET) and magnetic resonance imaging (MRI) have revolutionized the disease characterization as they enable the simultaneous measurement of functional and anatomical information of the body. However, the whole body simultaneous PET/MRI has been limited by its high cost. To address this issue, we are developing an RF-transmissive PET insert system that can be inserted into...
We are developing a brain positron emission tomography (PET) system prototype with long optical cables to minimize mutual interference between our PET components and magnetic resonance imaging (MRI) system. Our PET system consists of 16 PET detector modules which are placed in Faraday cages spaced equally in a 32 cm diameter ring. By using 20 m length optical cables rather than electrical connections,...
We evaluated the timing performance of our data acquisition system (DAQ) with compressed sensing detectors we used in a PET insert for simultaneous PET/MR brain imaging. Compressed sensing is a promising multiplexing method that can achieve high multiplexing ratio while resolving simultaneous hits on multiple pixels without serious degradation of timing and energy resolution for positron emission...
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