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Myonecrosis, in addition to edema and other biological manifestations, are conspicuous effects of Bothrops snake venoms, some of them caused by phospholipases A 2 (PLA 2 s). Asp49-PLA 2 s are catalytically active, whereas Lys49-PLA 2 s, although highly toxic, have little or no enzymatic activity upon artificial substrates, due to a substitution of lysine for aspartic...
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