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Herein, a kind of multi-responsive core-crosslinked poly (thiolether ester) micelles was facilely prepared for reactive oxygen species (ROS), acid and reduction sensitive drug delivery. Firstly, a hydroxyl-rich poly (thiolether ester) (PTE) was synthesized by the thiol-ene/thiol-expoxy polymerization using ethanedithiol (EDT) and glycidylmethacrylate (GMA) as monomers. The resultant PTE was then coupled...
Novel biodegradable and pH-sensitive hydrogels composed of four types of pH-sensitive polyacrylic acid derivatives (PAAD) and a biodegradable poly(l-glutamic acid) (PGA) crosslinker were synthesized and characterized for oral delivery of proteins or peptides. The swelling ratios of hydrogels in buffer solutions showed a pH-dependent profile at different pH values. Insulin was loaded into the hydrogels...
This paper describes smart hydrogels composed of pH-sensitive poly(acrylic acid) (PAA) and biodegradable temperature-sensitive hydroxypropylcellulose-g-acrylic acid (HPC-g-AA) for controlled drug delivery applications. In a pH-responsive manner, the hydrogels with the higher HPC-g-AA content resulted in the lower equilibrium swelling. Although temperature had little influence on the swelling of the...
A novel biodegradable AB-type diblock copolymer poly(L-lactic- co-glycolic acid)-block-poly(l-glutamic acid) (PLGA-b-PGA) was synthesized by a macromolecular coupling reaction between carboxyl-terminated PLGA and amino-terminated poly(γ-benzyl-glutamate) (PBLG) and the subsequent elimination of the protecting benzyl group. The structures of PLGA–PGA and its precursors were confirmed by Fourier transform...
Novel intelligent hydrogels composed of biodegradable and pH-sensitive poly(l-glutamic acid) (PGA) and temperature sensitive poly(N-isopropylacrylamide-co-2-hydroxyethyl methacrylate) (PNH) were synthesized and characterized for controlled release of hydrophilic drug. The influence of pH on the equilibrium swelling ratios of the hydrogels was investigated. A higher PNH content resulted in lower equilibrium...
A series of chromium/Schiff base complexes N,N′-bis(salicylidene)-1,2-phenylenediamino chromium III X were prepared and employed for the alternating copolymerization of carbon dioxide with racemic propylene oxide in the presence of (4-dimethylamino)pyridine. The effect of the complex structure and reaction conditions on the catalytic activity, the poly(propylene carbonate)/cyclic carbonate...
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