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To characterize LysM‐Cre mediated gene targeting in mice, we crossed LysM‐Cre mice to two independent reporter‐mouse lines (tdTomato or YFP). Surprisingly, we found that more than 90% of cells with LysM‐Cre mediated recombination in the brain were neurons, rather than myeloid cells, such as microglia. Hence, by using the LysM‐Cre mouse line for conditional knockout approaches, a significant neuronal...
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