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Aim
This study aimed to describe the change in surgical practice and the impact of SARS‐CoV‐2 on mortality after surgical resection of colorectal cancer during the initial phases of the SARS‐CoV‐2 pandemic.
Method
This was an international cohort study of patients undergoing elective resection of colon or rectal cancer without preoperative suspicion of SARS‐CoV‐2. Centres entered data from their...
Background
BRAF inhibitors are effective in melanoma and other cancers with BRAF mutations; however, patients ultimately develop therapeutic resistance through the activation of alternative signaling pathways such as RAF/RAS or MET. The authors hypothesized that combining the BRAF inhibitor vemurafenib with either the multikinase inhibitor sorafenib or the MET inhibitor crizotinib could overcome...
Cancer is a class of diseases characterized by out-of-control cell growth, which are the building blocks of the body. Imatinib, known by its brand-Gleevec, is a type of biological therapy called tyrosine kinase inhibitor (TKI) which, a chemical messenger, is protein that cells use to signal each other to grow and thus pro-motes cancer. Structure-based method includes inverse docking was used to anticipate...
Glioblastoma, the most common and aggressive malignant brain tumor, is propagated by stem-like cancer cells refractory to existing therapies. Understanding the molecular mechanisms that control glioblastoma stem cell (GSC) proliferation and drug resistance may reveal opportunities for therapeutic interventions. Here we show that GSCs can reversibly transition to a slow-cycling, persistent state in...
An Improved Constructive Semi-Supervised Classification Algorithm (ICS-SCA) is proposed to handle the problem of overlapping among hyperspheres of different classes. The overlapping problem occurs in Constructive Semi-Supervised Classification Algorithm proposed in [1]. Unlike CS-SCA[1], approach proposed here handles the samples lying in overlapping region of hyperspheres belonging to the different...
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