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Background:Old age and dyslipidemia increase the occurrence of atrial tachyarrhythmias (ATR). This study investigated the effect of age and hypercholesterolemia on the atrial substrates for ATR.Methods:Five 3‐year‐old rabbits fed standard chow were categorized into an old‐age group, five 3‐month‐old rabbits fed high cholesterol chow were used as a hypercholesterolemia group, and five 3‐month‐old rabbits fed standard chow were controls. Effective refractory period, atrial vulnerability to ATR, expressions of connexin40 (Cx40) and connexin43 (Cx43), phosphorylated c‐Jun N‐terminal Kinase (P‐JNK), and degree of fibrosis in the right (RA) and left (LA) atria were compared....
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