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Recent studies indicate that the protein products of genes involved in transcriptional regulation play an important role in light-induced phase-shifting of the circadian clock, and suggest that protein synthesis may be necessary for some critical steps in the process by which light can induce a phase shift. In order to determine if this protein-dependent step occurs before, during or at some time...
In chick pineal cells, melatonin synthesis is regulated by both calcium and cAMP. Calcium-dependent regulation of melatonin is suggested by the monotonic decrease in melatonin observed with decreasing extracellular calcium ion concentrations ([Ca 2+ ] o ), the stimulation of melatonin with Bay K8644, and the inhibition of nocturnal melatonin by several calmodulin antagonists...
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