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Thyroid hormones (THs) synthesised and released by the thyroid follicles in fish circulate bound to TH distributor proteins (THDPs). Transthyretin (TTR) is a tetrameric THDP with a conserved structure in vertebrates and functions as a high affinity T4 binder in tetrapods and as a dual T3/T4 binder in fish. The difference in TH affinity appears to be linked to the longer N-terminal region in piscine...
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