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Four new lipophilic analogues of the natural pyrone pironetin have been prepared. The C9 side‐chain of the latter has been replaced in one analogue by a 4‐phenylbutyl chain and in the other three analogues by C13 or C16 aliphatic chains, all of them bearing two stereogenic centres. Their cytotoxic activities and interactions with tubulin have been investigated. It was found that all four are cytotoxic...
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