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To clarify the pathogenesis of hepatitis C virus (HCV), we have studied the effects of HCV proteins using human hepatocytes. Here, we found that HCV NS5B, an RNA-dependent RNA polymerase, delayed cell cycle progression through the S phase in PH5CH8 immortalized human hepatocyte cells. Since treatment with anti-interferon (IFN)-β neutralizing antibody restored the cell cycle delay, IFN-β was deemed...
We previously found that hepatitis C virus (HCV) core protein (Core) activated the interferon (IFN)-inducible 40/46kDa 2′-5′-oligoadenylate synthetase (2′-5′-OAS) gene through an IFN-stimulated response element (ISRE) in non-neoplastic human hepatocyte PH5CH8 cells. Here, we found that Core and NS5B synergistically enhanced the 2′-5′-OAS gene promoter activity through ISRE. Further analysis revealed...
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