Search results for: Karam F.A. Soliman

Items from 1 to 20 out of 28 results

article

The attenuating effects of plumbagin on pro-inflammatory cytokine expression in LPS-activated BV-2 microglial cells

Samia S. Messeha, Najla O. Zarmouh, Patricia Mendonca, Malak G. Kolta, more

Journal of Neuroimmunology > 2017 > 313 > C > 129-137

Activated microglial cells produce the pro-inflammatory mediators such as nitric oxide (NO) and cytokines. The excessive release of these mediators can lead to neurodegenerative diseases, such as Alzheimer's disease (AD) and Parkinson's disease (PD). Inhibition of the release of these pro-inflammatory molecules may prevent or halt the progression of these diseases. Plumbagin (PL), a naphthoquinone...

article

The attenuating effects of 1,2,3,4,6 penta-O-galloyl-β-d-glucose on inflammatory cytokines release from activated BV-2 microglial cells

Patricia Mendonca, Equar Taka, David Bauer, Makini Cobourne-Duval, more

Journal of Neuroimmunology > 2017 > 305 > C > 9-15

Alzheimer's disease (AD) is the most common cause of neurodegeneration and dementia in the elderly. Dysregulated, chronic activation of microglia, the brain's resident macrophages, induces the release of excessive amounts of pro-inflammatory cytokines which has been implicated in the early stages of AD pathology. Therefore, suppressing the expression of these inflammatory mediators may decrease or...

article

Natural product HTP screening for attenuation of cytokine-induced neutrophil chemo attractants (CINCs) and NO2− in LPS/IFNγ activated glioma cells

Elizabeth A Mazzio, David Bauer, Patricia Mendonca, Equar Taka, more

Journal of Neuroimmunology > 2017 > 302 > C > 10-19

Chronic and acute central nervous system (CNS) inflammation are contributors toward neurological injury associated with head trauma, stroke, infection, Parkinsons or Alzheimers disease. CNS inflammatory illnesses can also contribute toward risk of developing glioblastoma multiforme (GBM). With growing public interest in complementary and alternative medicines (CAMs), we conduct a high throughput (HTP)...

article

Anti-inflammatory effects of thymoquinone in activated BV-2 microglial cells

Equar Taka, Elizabeth A. Mazzio, Carl B. Goodman, Natalie Redmon, more

Journal of Neuroimmunology > 2015 > 286 > Complete > 5-12

Thymoquinone (TQ), the main pharmacological active ingredient within the black cumin seed (Nigella sativa) is believed to be responsible for the therapeutic effects on chronic inflammatory conditions such as arthritis, asthma and neurodegeneration. In this study, we evaluated the potential anti-inflammatory role of TQ in lipopolysaccharide (LPS)-stimulated BV-2 murine microglia cells. The results...

article

Manganese-induced oxidative DNA damage in neuronal SH-SY5Y cells: Attenuation of thymine base lesions by glutathione and N-acetylcysteine

Adrienne P. Stephenson, Jeffrey A. Schneider, Bryant C. Nelson, Donald H. Atha, more

Toxicology Letters > 2013 > 218 > 3 > 299-307

Manganese (Mn) is an essential trace element required for normal function and development. However, exposure to this metal at elevated levels may cause manganism, a progressive neurodegenerative disorder with neurological symptoms similar to idiopathic Parkinson's disease (IPD). Elevated body burdens of Mn from exposure to parental nutrition, vapors in mines and smelters and welding fumes have been...

article

Microarray genomic profile of mitochondrial and oxidant response in manganese chloride treated PC12 cells

Equar Taka, Elizabeth Mazzio, Karam F.A. Soliman, R. Renee Reams

Neurotoxicology > 2012 > 33 > 2 > 162-168

Environmental or occupational exposure to high levels of manganese (Mn) can lead to manganism, a symptomatic neuro-degenerative disorder similar to idiopathic Parkinson's disease. The underlying mechanism of Mn neurotoxicity remains unclear. In this study, we evaluate the primary toxicological events associated with MnCl ₂ toxicity in rat PC12 cells using whole genome cDNA microarray, RT-PCR,...

article

Effects of NMDA receptor inhibition by phencyclidine on the neuronal differentiation of PC12 cells

Eunsook Lee, Zakia Williams, Carl B. Goodman, Ebenezer T. Oriaku, more

Neurotoxicology > 2006 > 27 > 4 > 558-566

Phencyclidine (PCP) is a non-competitive N-methyl-d-aspartate (NMDA) receptor antagonist and exposing the developing brain to PCP has been shown to cause deficits in neurobehavioral functions. In the present study we tested the effects of PCP, as an NMDA receptor inhibitor, on the neuronal differentiation and biogenic amines levels including norepinephrine (NE), epinephrine, dopamine, 3,4-dihydroxyphenylacetic...

article

The potentiating effects of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) on paraquat-induced neurochemical and behavioral changes in mice

K. Raviie Shepherd, Eun-Sook Y. Lee, Larry Schmued, Yun Jiao, more

Pharmacology, Biochemistry and Behavior > 2006 > 83 > 3 > 349-359

Although the etiology of Parkinson's disease (PD) is not fully understood, there are numerous studies that have linked the increased risk for developing PD to pesticides exposure including paraquat (PQ). Moreover, the exposure to a combination of compounds or chemical mixtures has been suggested to further increase this risk. In the current study, the effects of PQ on the nigrostriatal dopaminergic...

article

The Role of Phospholipid Methylation in 1-Methyl-4-Phenyl-Pyridinium Ion (MPP+)-Induced Neurotoxicity in PC12 Cells

Eun-Sook Y. Lee, Hongtao Chen, Clivel G. Charlton, Karam F.A. Soliman

Neurotoxicology > 2005 > 26 > 6 > 945-957

Excessive methylation has been proposed to be involved in the pathogenesis of Parkinson's disease (PD), via mechanisms that involve phospholipid methylation. Meanwhile, 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) was found to stimulate phospholipid methylation via the oxidized metabolite, 1-methyl-4-phenyl-pyridinium (MPP ⁺ ), in the rat brain and liver tissues. In the present study,...

article

Effects of Homocysteine on the Dopaminergic System and Behavior in Rodents

Eun-Sook Y. Lee, Hongtao Chen, Karam F.A. Soliman, Clivel G. Charlton

Neurotoxicology > 2005 > 26 > 3 > 361-371

Long-term treatment of levodopa for Parkinson's disease (PD) patients is known to elevate homocysteine level in their plasma. The present study was designed to examine the possible neurotoxic effects of the increased homocysteine level on the dopaminergic system. Homocysteine was administered into Sprague–Dawley male rats intracerebroventricularly or C57BL/6 mice intraperitoneally. Following homocysteine...

article

Lysophosphatidylcholine Decreases Locomotor Activities and Dopamine Turnover Rate in Rats

Eun-Sook Y. Lee, Karam F.A. Soliman, Clivel G. Charlton

Neurotoxicology > 2005 > 26 > 1 > 27-38

Lysophosphatidylcholine (lyso-PTC), a secondary product of S-adenosylmethionine (SAM)-dependent phosphatidylethanolamine (PTE) methylation, is a potent cytotoxin and might be involved in the pathogenesis of Parkinson's disease (PD). Our previous studies showed that the injection of SAM into the brain caused PD-like changes in rodents. Moreover, 1-methyl-4-phenylpyridinium (MPP ⁺ ), a Parkinsonism-inducing...

article

Inhibitory Effects of Cigarette Smoke on Glial Inducible Nitric Oxide Synthase and Lack of Protective Properties Against Oxidative Neurotoxins In Vitro

Elizabeth A. Mazzio, Malak G. Kolta, R. Renee Reams, Karam F.A. Soliman

Neurotoxicology > 2005 > 26 > 1 > 49-62

Epidemiological studies consistently report an inverse correlation between cigarette smoking and associated risk for Parkinson's disease (PD). The degeneration of dopaminergic neurons may involve the toxic metabolic products of glial cell monoamine oxidase (MAO) and inducible nitric oxide synthase (iNOS). This study evaluates the direct protective effects of cigarette smoke (CS) against potential...

article

Erratum to ''Effects of enhancing mitochondrial oxidative phosphorylation with reducing equivalents and ubiquinone on 1-methyl-4-phenylpyridinium toxicity and complex I-IV damage in neuroblastoma cells'' - [Biochem. Pharmacol. 67 (2004) 1167-1184]

Elizabeth A. Mazzio, Karam F.A. Soliman

Biochemical Pharmacology > 2004 > 67 > 9 > 1809

article

The role of oxidative stress, impaired glycolysis and mitochondrial respiratory redox failure in the cytotoxic effects of 6-hydroxydopamine in vitro

Elizabeth A. Mazzio, Renee R. Reams, Karam F.A. Soliman

Brain Research > 2004 > 1004 > 1-2 > 29-44

The neurotoxin, 6-hydroxydopamine (6-OHDA) has been implicated in the neurodegenerative process of Parkinson's disease. The current study was designed to elucidate the toxicological effects of 6-OHDA on energy metabolism in neuroblastoma (N-2A) cells. The toxicity of 6-OHDA corresponds to the total collapse of anaerobic/aerobic cell function, unlike other mitochondrial toxins such as MPP+ that target...

article

Effects of enhancing mitochondrial oxidative phosphorylation with reducing equivalents and ubiquinone on 1-methyl-4-phenylpyridinium toxicity and complex I-IV damage in neuroblastoma cells

Elizabeth A. Mazzio, Karam F.A. Soliman

Biochemical Pharmacology > 2004 > 67 > 6 > 1167-1184

The effects of increasing mitochondrial oxidative phosphorylation (OXPHOS), by enhancing electron transport chain components, were evaluated on 1-methyl-4-phenylpyridinium (MPP+) toxicity in brain neuroblastoma cells. Although glucose is a direct energy source, ultimately nicotinamide and flavin reducing equivalents fuel ATP produced through OXPHOS. The findings indicate that cell respiration/mitochondrial...

article

The inhibitory role of methylation on the binding characteristics of dopamine receptors and transporter

Eun-Sook Y. Lee, Hongtao Chen, Kennie R. Shepherd, Nazarius S. Lamango, more

Neuroscience Research > 2004 > 48 > 3 > 335-344

Excess methylation has been suggested to play a role in the pathogenesis of Parkinson's disease (PD), since the administration of S-adenosylmethionine (SAM), a biological methyl donor, induces PD-like changes in rodents. It was proposed that SAM-induced PD-like changes might be associated with its ability to react with the dopaminergic system. In the present study the effects of SAM on dopamine receptors...

article

Acetyl-l-carnitine cytoprotection against 1-methyl-4-phenylpyridinium toxicity in neuroblastoma cells

Elizabeth Mazzio, Kyoung J. Yoon, Karam F.A. Soliman

Biochemical Pharmacology > 2003 > 66 > 2 > 297-306

Acetyl-l-carnitine (ALCAR) plays an integral role in the transport of long chain fatty acids across the inner mitochondrial membrane for oxidative phosphorylation. In non-human primates, administration of ALCAR was reported to prevent 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced neurological injury to the substantia nigra. The present study investigates the effects of ALCAR against...

article

Inflammation and inducible nitric oxide synthase have no effect on monoamine oxidase activity in glioma cells

Elizabeth Mazzio, Alan Becker, Karam F.A. Soliman

Biochemical Pharmacology > 2003 > 65 > 10 > 1719-1727

Heightened monoamine oxidase (MAO) and inducible nitric oxide synthase (iNOS) activity can contribute to oxidative stress, the formation of active neurotoxins, and associated neurodegenerative diseases of the brain. Although these enzymes co-exist within astrocytes, there has been little research examining the correlation between the two during inflammation. In this study, C6 glioma cells were stimulated...

article

Effects of postnatal PCP treatment on locomotor behavior and striatal D ₂ receptor

Ratna Sircar, Karam F.A. Soliman

Pharmacology, Biochemistry and Behavior > 2003 > 74 > 4 > 943-952

Exposing the developing brain to the N-methyl-d-aspartate (NMDA) receptor antagonist phencyclidine (PCP) has been shown to cause deficits in neurobehavioral functions, particularly on learning and memory and seizure sensitivity. Besides acting as a noncompetitive NMDA antagonist, PCP at high doses is known to affect the dopaminergic system. The present study assessed the effect of postnatal PCP treatment...

article

Pyruvic acid cytoprotection against 1-methyl-4-phenylpyridinium, 6-hydroxydopamine and hydrogen peroxide toxicities in vitro

Elizabeth Mazzio, Karam F.A. Soliman

Neuroscience Letters > 2003 > 337 > 2 > 77-80

The neuropathology of Parkinson's disease (PD) involves a reduction of endogenous antioxidant enzyme systems, heightened oxidative stress and mitochondrial aberrations in the region of the substantia nigra. Similarly, neurotoxins commonly used to investigate PD pathology include 6-hydroxydopamine (6-OHDA), a powerful hydrogen peroxide (H ₂ 0 ₂ ) pro-oxidant and 1-methyl-4-phenylpyridinium...

Publication date

Set your own date range

INFONA - science communication portal

Search results for: Karam F.A. Soliman

The attenuating effects of plumbagin on pro-inflammatory cytokine expression in LPS-activated BV-2 microglial cells

The attenuating effects of 1,2,3,4,6 penta-O-galloyl-β-d-glucose on inflammatory cytokines release from activated BV-2 microglial cells

Natural product HTP screening for attenuation of cytokine-induced neutrophil chemo attractants (CINCs) and NO2− in LPS/IFNγ activated glioma cells

Anti-inflammatory effects of thymoquinone in activated BV-2 microglial cells

Manganese-induced oxidative DNA damage in neuronal SH-SY5Y cells: Attenuation of thymine base lesions by glutathione and N-acetylcysteine

Microarray genomic profile of mitochondrial and oxidant response in manganese chloride treated PC12 cells

Effects of NMDA receptor inhibition by phencyclidine on the neuronal differentiation of PC12 cells

The potentiating effects of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) on paraquat-induced neurochemical and behavioral changes in mice

The Role of Phospholipid Methylation in 1-Methyl-4-Phenyl-Pyridinium Ion (MPP+)-Induced Neurotoxicity in PC12 Cells

Effects of Homocysteine on the Dopaminergic System and Behavior in Rodents

Lysophosphatidylcholine Decreases Locomotor Activities and Dopamine Turnover Rate in Rats

Inhibitory Effects of Cigarette Smoke on Glial Inducible Nitric Oxide Synthase and Lack of Protective Properties Against Oxidative Neurotoxins In Vitro

Erratum to ''Effects of enhancing mitochondrial oxidative phosphorylation with reducing equivalents and ubiquinone on 1-methyl-4-phenylpyridinium toxicity and complex I-IV damage in neuroblastoma cells'' - [Biochem. Pharmacol. 67 (2004) 1167-1184]

The role of oxidative stress, impaired glycolysis and mitochondrial respiratory redox failure in the cytotoxic effects of 6-hydroxydopamine in vitro

Effects of enhancing mitochondrial oxidative phosphorylation with reducing equivalents and ubiquinone on 1-methyl-4-phenylpyridinium toxicity and complex I-IV damage in neuroblastoma cells

The inhibitory role of methylation on the binding characteristics of dopamine receptors and transporter

Acetyl-l-carnitine cytoprotection against 1-methyl-4-phenylpyridinium toxicity in neuroblastoma cells

Inflammation and inducible nitric oxide synthase have no effect on monoamine oxidase activity in glioma cells

Effects of postnatal PCP treatment on locomotor behavior and striatal D ₂ receptor

Pyruvic acid cytoprotection against 1-methyl-4-phenylpyridinium, 6-hydroxydopamine and hydrogen peroxide toxicities in vitro

Filter options

Publication date

Content availability

Keywords

Journal

INFONA - science communication portal

Search results for: Karam F.A. Soliman

Add recipient

Sending message cancelled

Are you sure you want to cancel sending this message?

Send message

Filter options

Publication date

Date range setting

Set the date range to filter the displayed results. You can set a starting date, ending date or both. You can enter the dates manually or choose them from the calendar.

Content availability

Keywords

Journal

Reporting an error / abuse

Sending the report failed

Accessibility options