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TGFβ1 is considered to be required for peripheral maintenance of CD4 + CD25 + FOXP3 + T reg cells. However, we demonstrate no reduction in the percentage of such T cells in the spleens and thymi of Tgfb1 −/− mice. Although putative T reg cells, characterized as CD4 + CD25 + FOXP3 + CD62L + T cells, are increased in Tgfb1...
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