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Poly(ADP-ribose) polymerases (PARPs) are a diverse group of proteins present in all multicellular eukaryotes. They catalyze the NAD + -dependent modification of proteins with poly(ADP-ribose). Poly(ADP-ribosyl)ation plays a key role in a plethora of processes including DNA repair, tumor progression and aging. Here we report that PaPARP, the single protein with a PARP catalytic domain, in the...
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