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Spinocerebellar ataxia type 1 (SCA1), due to an unstable polyglutamine expansion within the ubiquitously expressed Ataxin-1 protein, leads to the premature degeneration of Purkinje cells (PCs), decreasing motor coordination and causing death within 10–15 years of diagnosis. Currently, there are no therapies available to slow down disease progression. As secondary cellular impairments contributing...
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