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A sensitive and selective high-performance liquid chromatography–electrospray ionisation–tandem mass spectrometry (HPLC–ESI–MS–MS) method for determination of rosiglitazone in human plasma has been developed. After the addition of the internal standard, plasma samples were precipited by acetonitrile. The compounds were separated on a proC18 column using a mixture of ammonium acetate buffer (0.02M,...
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