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Specific antagonists of tumour necrosis factor (TNF)-α have rapidly gained popularity for the treatment of rheumatoid arthritis. The monoclonal antibody against TNF-α, infliximab, has been associated with induction of systemic lupus erythematosus (SLE); however, there have been no published reports of drug-induced SLE associated with the soluble TNF-α receptor etanercept. We describe four female patients...
Raynaud's phenomenon is characterised by episodic vasospasm of the fingers and toes typically precipitated by exposure to cold. Mild Raynaud's is common and is not usually a harbinger of clinically important disability; its onset, however, can be startling and uncomfortable for patients, and the well recognised association in some cases with systemic rheumatic conditions often precipitates aggressive...
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