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Purpose. To determine the maximally tolerated dose (MTD) of gemcitabine administered at a fixed dose-rate of 10mg/m2 per min in combination with fixed dose carboplatin, to evaluate the toxicity of this regimen and to determine the pharmacokinetics of plasma gemcitabine. Methods. Patients with advanced stage non-small-cell lung cancer (NSCLC) received carboplatin (AUC 5) on day1 followed by gemcitabine...
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