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We examined the effect of chronic exposure to lead (Pb 2+ ) on protein kinase C (PKC) in 50-day-old rat hippocampus. Cytosolic and membrane fractions of hippocampus from Pb 2+ -exposed rats showed reduced expression of PKCγ protein. In contrast, a significant elevation of PKCγ mRNA was observed in pyramidal and dentate granule cell layers. Protein expression of α, βI, βII...
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