Search results for: Hirokazu Kimura

Items from 1 to 20 out of 93 results

article

High attenuation mucus in bronchi with allergic bronchopulmonary mycosis

Shigeaki Hattori, Tsuyoshi Oguma, Takashi Ishiguro, Junko Suzuki, more

Mycoses > 67 > 2 > n/a - n/a

Background High‐attenuation mucus (HAM) is a specific manifestation of allergic bronchopulmonary mycosis (ABPM) on chest computed tomography (CT). Objectives To compare the diagnostic accuracy of the two definitions of HAM and to clarify the clinical and radiographic characteristics of HAM‐positive and HAM‐negative ABPM. Methods CT images at the diagnosis of ABPM using Asano's criteria were retrospectively...

article

Cytological features of human papillomavirus‐infected immature squamous metaplastic cells from cervical intraepithelial neoplasia grade 2

Mitsuaki Okodo, Kaori Okayama, Koji Teruya, Ruku Shinohara, more

Journal of Medical Virology > 95 > 12 > n/a - n/a

In reflex cytology, the presence of prominent nucleoli in immature metaplastic squamous cells (IM) may be underdiagnosed due to variations in interpretation. The aim of this study is to identify human papillomaviruses (HPVs) that infect IM clusters in cervical intraepithelial neoplasia 2 (CIN2) on Papanicolaou (Pap) smears to determine the cytological features of lesion‐derived cells. Thirty‐two patients...

article

Allergic bronchopulmonary aspergillosis with atopic, nonatopic, and sans asthma—Factor analysis

Naoki Okada, Yoshiro Yamamoto, Tsuyoshi Oguma, Jun Tanaka, more

Allergy > 78 > 11 > 2933 - 2943

Background Allergic bronchopulmonary aspergillosis (ABPA) develops in the presence or absence of asthma, either atopic or nonatopic. We have tried to explore the essential components in the pathogenesis of the disease, which are either consistent and variable according to the presence and type of asthma. Methods Non‐cystic fibrosis ABPA cases satisfying Asano's criteria were extracted from a prospective...

article

Effect of Compounds from Moringa oleifera Lam. on in Vitro Non‐Alcoholic Fatty Liver Disease (NAFLD) Model System

Motohiko Ukiya, Kazuki Motegi, Daisuke Sato, Hirokazu Kimura, more

Chemistry & Biodiversity > 18 > 7 > n/a - n/a

Non‐alcoholic fatty liver disease (NAFLD) is currently the most common chronic liver disease in the world, with a prevalence of 25 % in many countries. To date, no drug has been approved to treat NAFLD, therefore, the use of phytochemicals to prevent this disease is meaningful. In this study, we focused on the effects of Moringa oleifera Lam. on diabetes, attempted to isolate compounds that regulate...

article

Koilocytic changes are not elicited by human papillomavirus genotypes with higher oncogenic potential

Mitsuaki Okodo, Kaori Okayama, Koji Teruya, Hirokazu Kimura, more

Journal of Medical Virology > 92 > 12 > 3766 - 3773

Koilocytes are considered a common cytopathological effect in patients with human papillomavirus (HPV) infection. Thus, we aimed to elucidate whether koilocytes are common to all HPV infections. Liquid‐based cytology samples from 651 patients with abnormal Papanicolaou (Pap) test results were used to analyze the presence of koilocytes and HPV genotype. HPV genotype was determined in complete liquid...

article

Tokoronin Contained in Dioscorea tokoro Makino ex Miyabe Suppressed α‐MSH‐Induced Melanogenesis in B16 Cells via Suppression of Classical MAPK Pathway Activation

Motohiko Ukiya, Daisuke Sato, Hirokazu Kimura, Yasuaki Hirai, more

Chemistry & Biodiversity > 17 > 6 > n/a - n/a

In this study, melanogenesis inhibition in B16 cells by eight compounds, namely, tokorogenin, tokoronin, yononin, gracillin, proto‐yonogenin, proto‐tokoronin, proto‐yononin, and proto‐gracillin, isolated from Dioscorea tokoro Makino ex Miyabe were evaluated. The results of the cytotoxicity and α‐MSH‐induced melanogenesis inhibition effects of the eight compounds revealed that tokoronin was the most...

article

Variation of human norovirus GII genotypes detected in Ibaraki, Japan, during 2012–2018

Takumi Motoya, Masahiro Umezawa, Aoi Saito, Keiko Goto, more

Gut Pathogens > 2019 > 11 > 1 > 1-15

Background Human norovirus (HuNoV) is the major cause of viral acute gastroenteritis for all age groups in various countries. HuNoV GII in particular accounted for the majority of norovirus outbreaks, among which GII.4 caused repeated outbreaks for a long time. Besides GII.4, other norovirus genotypes, GII.2, GII.6, and GII.17, have also been prevalent in various contexts in recent years, but few...

article

Antidiabetic‐Like Effects of Naringenin‐7‐O‐glucoside from Edible Chrysanthemum ‘Kotobuki’ and Naringenin by Activation of the PI3K/Akt Pathway and PPARγ

Atsuyoshi Nishina, Daisuke Sato, Junpei Yamamoto, Kazuo Kobayashi‐Hattori, more

Chemistry & Biodiversity > 16 > 1 > n/a - n/a

Obesity is directly associated with cancer, cardiovascular injury, hypertension, and type 2 diabetes. To date, Yamamoto identified that hot water extracts of edible Chrysanthemum (EC) induced cell size reduction, up‐regulation of adiponectin expression, and glucose absorption inhibition in 3T3‐L1 cells during adipocyte differentiation. Furthermore, EC showed antidiabetic effects such as improvement...

article

Production and characterization of monoclonal antibodies specific for major capsid VP1 protein of trichodysplasia spinulosa‐associated polyomavirus

Hajera Khatun, Yutaro Yamaoka, Yuki Matsushima, Satoko Matsunaga, more

Microbiology and Immunology > 62 > 12 > 763 - 773

Trichodysplasia spinulosa‐associated polyomavirus (TSPyV), a newly identified polyomavirus, has been implicated as a causative agent of trychodysplasia spinulosa (TS), a rare proliferative skin disease in severely immunocompromised hosts. Diagnosis using mAbs is a promising tool with high specificity towards the specific antigen. However, thus far, no suitable mAbs for diagnosing TS disease have...

article

Correlation between clinical features, high-resolution computed tomography findings, and a visual scoring system in patients with pneumonia due to Mycoplasma pneumoniae

Takeshi Saraya, Kosuke Ohkuma, Yayoi Tsukahara, Takayasu Watanabe, more

Respiratory Investigation > 2018 > 56 > 4 > 320-325

Mycoplasma pneumoniae (MP) is the primary cause of community-acquired pneumonia. We aimed to evaluate the correlation between clinical features, with special reference to hypoxemia and the total affected area obtained using high-resolution computed tomography (HRCT).Medical records of MP pneumonia patients > 15 years of age at Kyorin University Hospital between January 2006 and November 2013 were...

article

Diagnostic Value of Vascular Endothelial Growth Factor, Transforming Growth Factor-β, Interleukin-8, and the Ratio of Lactate Dehydrogenase to Adenosine Deaminase in Pleural Effusion

Takeshi Saraya, Kosuke Ohkuma, Takayasu Watanabe, Sunao Mikura, more

Lung > 2018 > 196 > 2 > 249-254

Purpose We studied the diagnostic value of cytokines, including vascular endothelial growth factor (VEGF), transforming growth factor-β (TGF-β), and interleukin-8 (IL-8), and the ratio of lactate dehydrogenase (LDH) to adenosine deaminase (ADA) in pleural fluid. Methods Prospective analysis of 44 inpatients or outpatients with pleural fluid, from December 2016 to March 2017 was conducted. Results...

article

The Dickkopf1‐cytoskeleton‐associated protein 4 axis creates a novel signalling pathway and may represent a molecular target for cancer therapy

Akira Kikuchi, Katsumi Fumoto, Hirokazu Kimura

British Journal of Pharmacology > 174 > 24 > 4651 - 4665

Dickkopf 1 (DKK1) is a secreted protein and antagonizes oncogenic Wnt signalling by binding to the Wnt co‐receptor, low‐density lipoprotein receptor‐related protein 6. DKK1 has also been suggested to regulate its own signalling, associated with tumour aggressiveness. However, the underlying mechanism by which DKK1 promotes cancer cell proliferation has remained to be clarified for a long time. The...

article

Occurrence of norovirus infection in an asymptomatic population in Indonesia

Takako Utsumi, Maria Inge Lusida, Zayyin Dinana, Rury Mega Wahyuni, more

Infection, Genetics and Evolution > 2017 > 55 > C > 1-7

Norovirus (NoV) is a major cause of nonbacterial acute gastroenteritis worldwide in all age groups, and asymptomatic individuals may contribute to NoV transmission as a reservoir. Nonetheless, little information is available regarding asymptomatic NoV infection in Indonesia. We performed an epidemiological analysis of NoV infection among asymptomatic healthy volunteers in the city of Surabaya, Indonesia...

article

Reduction in the prevalence of AmpC β-lactamase CMY-2 in Salmonella from chicken meat following cessation of the use of ceftiofur in Japan

Yui Kataoka, Koichi Murakami, Yasushi Torii, Hirokazu Kimura, more

Journal of Global Antimicrobial Resistance > 2017 > 10 > C > 10-11

article

Simultaneous oral administration of Salmonella Infantis and S. Typhimurium in chicks

Koichi Murakami, Eriko Maeda-Mitani, Daisuke Onozuka, Tamie Noda, more

Irish Veterinary Journal > 2017 > 70 > 1 > 1-6

Background To confirm the hypothesis that Salmonella enterica subspecies enterica serovar (S.) Infantis has higher basic reproductive rates in chicks compared with other Salmonella serovars, 1-day-old specific-pathogen-free chicks (n = 8) were challenged simultaneously with S. Infantis and S. Typhimurium per os. Challenged chicks (Group A) were then housed with non-infected chicks (Group B, n = 4)...

article

A method for detecting rash and fever illness‐associated viruses using multiplex reverse transcription polymerase chain reaction

Yuki Matsushima, Tomomi Shimizu, Ikuko Doi, Fuminori Mizukoshi, more

Microbiology and Immunology > 61 > 8 > 337 - 344

In this study, a new multiplex RT‐PCR method for detecting various viral genes in patients with rash and fever illnesses (RFIs) was constructed. New primer sets were designed for detection of herpes simplex viruses 1 and 2 (HSV1 and 2), and Epstein–Barr virus (EBV). The newly designed and previously reported primer sets were used to detect 13 types of RFI‐associated viruses by multiplex RT‐PCR assay...

article

Molecular evolution of the fusion protein (F) gene in human respiratory syncytial virus subgroup B

Hirokazu Kimura, Koo Nagasawa, Ryusuke Kimura, Hiroyuki Tsukagoshi, more

Infection, Genetics and Evolution > 2017 > 52 > C > 1-9

In this study, we examined the molecular evolution of the fusion protein (F) gene in human respiratory syncytial virus subgroup B (HRSV-B). First, we performed time-scale evolution analyses using the Bayesian Markov chain Monte Carlo (MCMC) method. Next, we performed genetic distance, linear B-cell epitope prediction, N-glycosylation, positive/negative selection site, and Bayesian skyline plot analyses...

article

Acute bronchodilator responses to β2-agonist and anticholinergic agent in COPD: Their different associations with exacerbation

Satoshi Konno, Hironi Makita, Masaru Suzuki, Kaoruko Shimizu, more

Respiratory Medicine > 2017 > 127 > C > 14-20

Acute bronchodilator response (BDR) is a potential phenotypic characteristic of COPD. However, the clinical factors associated with BDR in patients with COPD remain unclear, particularly for BDR to anticholinergic agents.We aimed to clarify the clinical factors associated with BDR to β2-agonist and/or anticholinergic agent, considering time-associated variations of BDR. We also evaluated the association...

article

Poly I:C induces collective migration of HaCaT keratinocytes via IL-8

Kazuhide Takada, Shihoko Komine-Aizawa, Naoko Hirohata, Quang Duy Trinh, more

BMC Immunology > 2017 > 18 > 1 > 1-10

Background Delayed wound healing reduces the quality of life (QOL) of patients. Thus, understanding the mechanism of wound healing is indispensable for better management. However, the role of innate immunity in wound healing is thus far unknown. Recently the involvement of TLR3 in wound healing has been evaluated. The systemic administration of polyriboinosinic-polyribocytidylic acid (poly I:C ; a...

article

Molecular evolution of respiratory syncytial virus subgroup A genotype NA1 and ON1 attachment glycoprotein (G) gene in central Vietnam

Keisuke Yoshihara, Minh Nhat Le, Koo Nagasawa, Hiroyuki Tsukagoshi, more

Infection, Genetics and Evolution > 2016 > 45 > C > 437-446

We performed molecular evolutionary analyses of the G gene C-terminal 3rd hypervariable region of RSV-A genotypes NA1 and ON1 strains from the paediatric acute respiratory infection patients in central Vietnam during the 2010–2012 study period. Time-scaled phylogenetic analyses were performed using Bayesian Markov Chain Monte Carlo (MCMC) method, and pairwise distances (p-distances) were calculated...

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INFONA - science communication portal

Search results for: Hirokazu Kimura

High attenuation mucus in bronchi with allergic bronchopulmonary mycosis

Cytological features of human papillomavirus‐infected immature squamous metaplastic cells from cervical intraepithelial neoplasia grade 2

Allergic bronchopulmonary aspergillosis with atopic, nonatopic, and sans asthma—Factor analysis

Effect of Compounds from Moringa oleifera Lam. on in Vitro Non‐Alcoholic Fatty Liver Disease (NAFLD) Model System

Koilocytic changes are not elicited by human papillomavirus genotypes with higher oncogenic potential

Tokoronin Contained in Dioscorea tokoro Makino ex Miyabe Suppressed α‐MSH‐Induced Melanogenesis in B16 Cells via Suppression of Classical MAPK Pathway Activation

Variation of human norovirus GII genotypes detected in Ibaraki, Japan, during 2012–2018

Antidiabetic‐Like Effects of Naringenin‐7‐O‐glucoside from Edible Chrysanthemum ‘Kotobuki’ and Naringenin by Activation of the PI3K/Akt Pathway and PPARγ

Production and characterization of monoclonal antibodies specific for major capsid VP1 protein of trichodysplasia spinulosa‐associated polyomavirus

Correlation between clinical features, high-resolution computed tomography findings, and a visual scoring system in patients with pneumonia due to Mycoplasma pneumoniae

Diagnostic Value of Vascular Endothelial Growth Factor, Transforming Growth Factor-β, Interleukin-8, and the Ratio of Lactate Dehydrogenase to Adenosine Deaminase in Pleural Effusion

The Dickkopf1‐cytoskeleton‐associated protein 4 axis creates a novel signalling pathway and may represent a molecular target for cancer therapy

Occurrence of norovirus infection in an asymptomatic population in Indonesia

Reduction in the prevalence of AmpC β-lactamase CMY-2 in Salmonella from chicken meat following cessation of the use of ceftiofur in Japan

Simultaneous oral administration of Salmonella Infantis and S. Typhimurium in chicks

A method for detecting rash and fever illness‐associated viruses using multiplex reverse transcription polymerase chain reaction

Molecular evolution of the fusion protein (F) gene in human respiratory syncytial virus subgroup B

Acute bronchodilator responses to β2-agonist and anticholinergic agent in COPD: Their different associations with exacerbation

Poly I:C induces collective migration of HaCaT keratinocytes via IL-8

Molecular evolution of respiratory syncytial virus subgroup A genotype NA1 and ON1 attachment glycoprotein (G) gene in central Vietnam

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