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Pancreatic ductal adenocarcinoma (PDAC) is the most common neoplastic disease of the pancreas, accounting for more than 90% of all pancreatic malignancies. As a highly lethal malignancy, PDAC is the fourth leading cause of cancer‐related deaths worldwide with a 5‐year overall survival of less than 8%. The efficacy and outcome of PDAC treatment largely depend on the stage of disease at the time of...