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Emodin is a naturally occurring anthraquinone derivative with a variety of pharmacologic effects, but its role and regulatory mechanism in colorectal cancer (CRC) remain to be investigated. Thus, the aim of this study is to explore the effect of emodin on CRC cells. A gradient of emodin and long noncoding RNA HCP5 overexpression plasmid/small interfering RNA targeting HCP5 (siHCP5) were used for treating...
A new series of DPP‐4 inhibitors with imidazo[1,2‐a]pyridine scaffold were designed by exploiting scaffold hopping strategy and docking study. Based on docking binding model, structural modifications of 2‐benzene ring and pyridine moieties of compound 5a led to the identification of compound 5d with 2, 4‐dichlorophenyl group at the 2‐position as a potent (IC50 = 0.13 μm), selective (DPP‐8/DPP‐4 = 215...
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