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A number of diseases affecting the CNS occur in the dog and can be used as models for gene therapy in a large brain. HSV-1 has several potential advantages as a vector to transfer genes into the CNS. However, the ability of HSV-1 to infect CNS cells varies among species and no information was available for the dog. When the nonpathogenic 1716 strain of HSV-1 was injected into the brains of normal...
A family of domestic cats was found that exhibited clinical and biochemical abnormalities consistent with mucopolysaccharidosis VII, an autosomal recessive lysosomal storage disorder caused by β-glucuronidase deficiency. β-Glucuronidase activity was undetectable in affected cat fibroblasts and restored by retroviral gene transfer of rat β-glucuronidase cDNA. β-Glucuronidase mRNA was normal in affected...
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