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Design of effective nanodrugs to modulate the immunosuppression of tumor microenvironment is a desirable approach to boost the clinical tumor‐therapeutic effect. Supramolecular nanomicelles PolyMN‐TO‐8, which are constructed by self‐assembling supramolecular host MTX‐MPEG2000, guest NPX‐2S, and TO‐8 through hydrophobic forces, have excellent stability and responsiveness to carboxylesterase and glutathione...
The programmable nature of DNA allows the construction of custom‐designed static and dynamic nanostructures, and assembly conditions typically require high concentrations of magnesium ions that restricts their applications. In other solution conditions tested for DNA nanostructure assembly, only a limited set of divalent and monovalent ions are used so far (typically Mg2+ and Na+). Here, we investigate...
DNA Nanostructures
Xing Wang, Arun Richard Chandrasekaran and co‐workers assembled DNA nanostructures in a wide variety of ions (Ca2+, Ba2+, Na+, K+ and Li+). Nanostructures assembled in monovalent ions (Na+, K+ and Li+) exhibit a higher nuclease resistance compared to those assembled in divalent ions (Mg2+, Ca2+ and Ba2+). In article number 2300040, the authors present new assembly conditions for...
It is challenging for traditional wound dressings to adapt to the complex and changeable environment, due to the lack of stable, efficient, and continuous bactericidal activity. They also cannot be satisfied in a multifunctional sensing platform to reconstruct skin sensory functions for human health monitoring. A multifunctional hydrogel dressing is developed here for the treatment of infected wounds...
Combination therapies that target multiple pathways involved in immune rejection of transplants hold promise for patients in need of restorative surgery. Herein, a noninteracting multiphase molecular assembly approach is developed to crystallize tofacitinib, a potent JAK1/3 inhibitor, within a shear‐thinning self‐assembled fibrillar peptide hydrogel network. The resulting microcrystalline tofacitinib...
In article number 1902086, Yanying Wang, Chunya Li, and co‐workers use ionic liquid–based Zn‐ metal–organic framework (MOF) as template for MoS2 nanoparticles synthesis, which are then carbonized to yield light‐responsive ZnS/C/MoS2 nanocomposites. ZnS/C/MoS2 nanocomposites can produce good photocurrent response under the excitation of visible light and are used as a photoactive element to construct...
A hexafluorophosphate ionic liquid is used as a functional monomer to prepare a metal–organic framework (Zn‐MOF). Zn‐MOF is used as a template for MoS2 nanosheets synthesis and further carbonized to yield light‐responsive ZnS/C/MoS2 nanocomposites. Zn‐MOF, carbonized‐Zn‐MOF, and ZnS/C/MoS2 nanocomposites are characterized by Fourier transform infrared spectroscopy, transmission electron microscopy,...
Precise control of DNA base pairing has rapidly developed into a field full of diverse nanoscale structures and devices that are capable of automation, performing molecular analyses, mimicking enzymatic cascades, biosensing, and delivering drugs. This DNA‐based platform has shown the potential of offering novel therapeutics and biomolecular analysis but will ultimately require clever modification...
DNA nanostructures offer new opportunities for diagnostics, therapeutics and biomolecular analysis. For that purpose, they require special modifications and functionalities. In article number 1805386, Megan E. Kizer, Robert J. Linhardt, Arun Richard Chandrasekaran, and Xing Wang discuss the properties needed to make DNA nanostructures applicable to in vitro and in vivo applications by drawing analogies...
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