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Background: Literature reports differ dramatically in showing that apolipoprotein E either facilitates or inhibits Aβ aggregate formation in vitro. Resolution of the nature of the ApoE-Aβ interaction is critical for progress towards understanding its possible role in the modulation of Alzheimer's disease.Results: Here, we show that purified ApoE-Aβ co-aggregate is a poor seed of fibril formation....
The behaviour of synthetic batches of beta-amyloid (βA) 1-40 peptide in solution has been studied. The effects of βA1-40 on a PC12 cell toxicity assay was dependent upon the time of preincubation of an aqueous solution of the peptide before application to the cells. Fibrillization of the βA1-40, quantitatively assessed by the binding of Congo red to amyloid fibrils, also increased in a time dependent...
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