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The 5-year survival rate for stage I non–small-cell lung cancer (NSCLC) of 50% to 70% indicates that our current staging methods do not adequately predict outcome. Empty spiracles homeobox 2 (EMX2) is a homeo–domain-containing transcription factor that regulates a key developmental pathway known to promote lung tumorigenesis. This study assessed the significance of EMX2 as a prognostic biomarker in...
Lung cancer is the leading cause among cancer-related deaths worldwide. The Wnt/β-catenin signaling pathway has been proven to be activated in non—small-cell lung cancer (NSCLC). We have previously reported that Dishevelled-3 (Dvl-3), interacting with the intracellular domain of Wnt signal receptor Frizzled (Fz) and functioning as a key mediator of the Wnt/β-catenin pathway, is over-expressed in NSCLC...
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