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The melanocortin system is involved in the regulation of several diverse physiological pathways, including energy homeostasis. Several synthetic peptide analogs have been designed, synthesized, and pharmacologically characterized at the mouse melanocortin receptor subtypes MC1R, MC3R, MC4R, and MC5R. These peptides incorporate modifications of the melanocortin core amino acids His-Phe-Arg-Trp by using...
SCHIÖTH, H. B., R. MUCENIECE, F. MUTULIS, P. PRUSIS, G. LINDEBERG, S. D. SHARMA, V. J. HRUBY AND J. E. S. WIKBERG.Selectivity of cyclic [d-Nal 7 ] and [d-Phe 7 ] substituted MSH analogues for the melanocortin receptor subtypes.PEPTIDES 18(7), 1009–1013, 1997.—The binding of the 2 cyclic lactam MSH (4–10) analogues (MTII, SHU9119), and 5 cyclic [Cys 4 , Cys 10 ]α-MSH...
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